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KMID : 0385520100230050457
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Analytical Science & Technology
2010 Volume.23 No. 5 p.457 ~ p.464
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The analysis of pharmaceuticals in drinking water by HPLC/ESI-MS/MS
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Park Mi-Sun
Kim Byung-Joo
Myung Seung-Woon
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Abstract
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The analytical method of four pharmaceuticals (virginiamycin, erythromycin, tylosin and cimetidine) in drinking water was developed. Effective simultaneous sample clean-up and extraction by solid-phase extraction (SPE) using HLB cartridge prior to LC/ESI-MS/MS analysis were performed. A linear correlation observed in the calibration curves for drinking water in the range of 0.01~2.0 ng/mL showed above r²=0.995. Absolute recovery was in the range of 64.7~118.1% (except cimetidine (37.7~48.1%)). Limit of detection (LOD) and limit of quantitation (LOQ) in spiked drinking water matrix were in the range of 1.6~74.8 pg/mL and 5.5~249.7 pg/mL, respectively. The established method can be used to determine low pg/mL levels of pharmaceuticals in the drinking water.
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KEYWORD
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macrolides, cimetidine, drinking water, LC/ESI-MS/MS
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